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Nucleic Acids Research, 1977, Vol. 4, No. 11 3919-3930
© 1977

Articles

A doubtful relationship between tyrosine tRNA and suppression of the vermilion mutant in Drosophila

Michael A. Wosnick and Bradley N. White

The Group in Eukaryotic Molecular Biology and Evolution, Department of Biology, Queen's University Kingston, Ontario, Canada

Received August 29, 1977. The conditions under which Drosophila melanogaster are grown markedly influence the amount of the hypermodified nucleoside Q found in certain tRNAs. This effect on Q biosynthesis was found in both the wild-type and the suppressor of sable [su(s)2] mutant. Suppressed vermilion flies [su(s)2v; bw] with 78% of the tyrosine tRNA in the Q-lacking ({gamma}) form had brown eyes indistinguishible from su(s)2v; bw flies with only 6% of the tyrosine tRNA in the {gamma} form. The proposal that this tRNA is a specific inhibitor of tryptophan pyrrolase in vermilion flies, and that its absence in su(s)2 flies is the mechanism of suppression is not consistent with these results. In addition, the su(s)2 locus does not seem to be primarily responsible for controlling Q biosynthesis as previously suggested.


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