Skip Navigation

This Article
Right arrow Print PDF (522K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Amalric, F.
Right arrow Articles by Caboche, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Amalric, F.
Right arrow Articles by Caboche, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1977, Vol. 4, No. 12 4357-4370
© 1977

Articles

RNA methylation and control of eukaryotic RNA biosynthesis: processing and utilization of undermethylated tRNAs in CHO cells

François Amalric*, Jean-Pierre Bachellerie* and Michel Caboche+,+

*Centre de Recherche de Biochimie et Génétique Cellulaires du C.N.R.S. 118, Route de Narbonne, 31077 Toulouse-Cedex, France +Laboratoire de Génétique Cellulaire, I.N.R.A. Toulouse, 31320 Castanet-Tolosan, France

Received October 15, 1977.

The role of RNA methylations in the control of tRNA production and utilization for protein biosynthesis has been investigated through a study of the effects in vivo of cycloleucine a specific and potent inhibitor of S adenosyl-methionine mediated methylation.

During the cycloleucine treatment, the rate of appearance of newly synthetized tRNAs into the cytoplasm is markedly reduced (about 50 %). These molecules are extensively (more than 90 %) undermethylated and are integrated into polysomes, but at a slower rate than normally methylated tRNAs.

+Present address: Laboratoire de Biologie Cellulaire, Centre National de la Recherche Agronomique, Route de Saint-Cyr, 78000 Versailles, France


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.