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Nucleic Acids Research, 1977, Vol. 4, No. 4 917-928
© 1977

Articles

Effect of homopolyribonucleotides on messenger ribonucleoprotein particles

Bo Sundquist{dagger} and Torgny Persson

Department of Microbiology, The Wallenberg Laboratory, Uppsala University Uppsala, Sweden

Received January 27, 1977.

A discrete set of polypeptides copurify with and appear to be specifically attached to mRNA from polysomes of eukaryotic cells. This report describes the effect of homopolyribonucleotides on mRNA-protein complexes separated from ribosome subunits by oligo(dT)-cellulose chroma-tography. It is shown that poly(U) and poly(A) can release mRNA-protein complexes adsorbed to oligo(dT)-cellulose, whereas poly(C) and poly(I) are much less effective in this process. Analysis of polyribonucleotide released material showed that poly(U) effectively dissociated the mRNA-protein complexes while poly(A) caused no or only partial derangement of these particles. The specificities seen in the polyribonucleotide effects in turn suggest a high degree of specificity in the interaction between the proteins and mRNA.

{dagger}Present address: Department of Virology, The Royal Veterinary College, Biomedicum, Box 585, S-751 23 Uppsala, Sweden.


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