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Nucleic Acids Research, 1977, Vol. 4, No. 5 1257-1266
© 1977

Articles

Estimation of DNA sequence divergence from comparison of restriction endonuclease digests*

William B. Upholt

Departments of Pediatrics and Biochemistry and the Joseph P. Kennedy, Jr. Mental Retardation Research Center, The University of Chicago Box 413, Chicago, IL 60637, USA

Received January 10, 1977.

An estimation of the DNA sequence divergence between defined DNA sequences of individuals or species may be made from comparison by gel elec-trophoresis of restriction endonuclease digests. This analysis is applicable to purified DNA sequences of moderate complexity (1–100 x 106 daltons) which have diverged by base substitution of 0.5 to 25% of nucleotides.

*Dedicated to Jerome Vinograd.


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