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Nucleic Acids Research, 1977, Vol. 4, No. 6 1881-1890
© 1977

Articles

Features of the structure of replicating and non-replicating chromatin in chicken erythroblasts

Dean Hewish

Biochemistry Department, the University of Adelaide North Terrace, Adelaide, 5000, South Australia

Received February 28, 1977. The digestion by DNAase I of DNA synthesised by isolated chicken erythroblasts was examined in isolated nuclei. It was found that newly synthesised DNA was susceptible to DNAase I but matured to a relatively resistant form with increasing time after replication as observed in mammalian systemsll,12. The presence of trypsin in the digestion exposed all of the DNA to DNAase I action. Examination of the digestion products showed that the newly replicated DNA differed little from the more mature form in the structure of the DNA-protein complex but that the difference in susceptibility was probably a result of a differential rate of access of the DNAase to the new and old DNA.


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