Skip Navigation

This Article
Right arrow Print PDF (396K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Jank, P.
Right arrow Articles by Gross, H. J.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Jank, P.
Right arrow Articles by Gross, H. J.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1977, Vol. 4, No. 6 1999-2008
© 1977

Articles

Rabbit liver tRNA1Val: I. Primary structure and unusual codon recognition

Peter Jank, Nobuko Shindo-Okada+, Susumu Nishimura+ and Hans J. Gross

Max-Planck-Institut fuür Biochemie , D-8033 Martinsried bei Muünchen, GFR +Biology Division, National Cancer Center Research Institute Tokyo, Japan.

Received March 29, 1977. The major valine acceptor Formula from rabbit liver was purified and its nucleotide sequence determined by in vitro [32p]- labeling with T4 phage induced polynucleotide kinase and fingerprinting techniques. Its primary structure was found to be identical with the major valine tRNA from mouse myeloma cells. According to the wobble hypothesis this tRNA, which exclusively has an IAC anticodon, should decode the valine codons GUU, GUC and GUA only. However, this tRNA recognizes all four valine codons with a surprising preference for GUG. It is unknown whether this is due to the lack of A37 modification next to the 3' end of the anticodon IAC. The nature of the inosine-guanosine interaction remains to be clarified.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.