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Nucleic Acids Research, 1977, Vol. 4, No. 8 2939-2947
© 1977

Articles

The role of the AT pairs in the acid denaturation of DNA

Ph. Hermann and E. Fredericq

Université de Liège, Service de Chimie-Physique Sart-Tilman, B-4000 Liège, Belgium

Received June 22, 1977. It has been determined previously that the protonation of the GC pairs induces a DNA conformation change which leads to a "metastable" structure. The role of the AT pairs, however, is not well known because the protonation does not modify their spectral properties. By means of an indirect method based on the binding of proflavine, it has been determined that the AT pairs are protonated before the acid-induced denaturation and that they seem to be unable to assume a conformation change when protonated. These results would indicate that the protonated AT pairs may be responsible for the induction of the acid denaturation and not the GC pairs as it was thought previously.


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