Skip Navigation

This Article
Right arrow Print PDF (276K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Cech, D.
Right arrow Articles by Holy, A.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Cech, D.
Right arrow Articles by Holy, A.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1977, Vol. 4, No. 9 3259-3266
© 1977

Articles

Fluorination of 6-methyluracil and its nucleosides

Dieter Cecha, Gottfried Herrmanna and Antonin Holyb

aSektion Chemie, Humboldt Universität Berlin, GDR 166 10 Praha, Czechoslovakia bInstitute of Organic Chemistry and Biochemistry, Czechoslovak Academy of Science 166 10 Praha, Czechoslovakia.

Received July 25, 1977. 6-Methyluracil and its perbenzoylated 1-(ß-D-ribofuranosyl) and 1-(2-deoxy-ß-D-ribofuranosyl) derivatives afford, on treatment with elemental fluorine in acetic acid solutions, the corresponding derivatives of 5-fluoro-6-methylurecil and 5-fluoro-6-fluoromethyluracil. The free nucleosides have been obtained from the protected derivatives by methanolysis. The CH2F linkage in 5-fluoro-6-fluoromethyluracil derivatives is stable towards hydrolysis and nucleophilic agents.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.