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Nucleic Acids Research, 1978, Vol. 5, No. 10 3619-3634
© 1978

Articles

Photochemical production of psoralen - DNA monoadducts capable of subsequent photocrosslinking

Pradeep K. Chatterjee and Charles R. Cantor

Departments of Chemistry and Biological Sciences, Columbia Univeisity New York, NY 10027, USA

Received June 26, 1978. Irradiation of 4'-aminomethyl-4, 5', 8-trimethyl psoralen in the presence of DNA at wavelengths between 380 and 400nm leads to efficient production of monoadducts with no significant amount of crosslinking. The yield of monoadduct attainable is high (about 35 adducts per 1000 base pairs) and can be made still higher by repeated irradiation with fresh psoralen derivative. Subsequent irradiation at 350nm results in crosslinking of almost half of the monoattached psoralen. Studies of the yield of monoadduct and crosslink as a function of irradiation wavelength show that the action spectrum for crosslink formation is blue-shifted relative to that for monoadduct formation.


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