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Nucleic Acids Research, 1978, Vol. 5, No. 11 4065-4076
© 1978

Articles

A new RNA-RNA crosslinking reagent and its application to ribosomal 5S RNA

Rolf Wagner and Roger A. Garrett

Max-Planck-Institut für Molekulare Genetik, Abt. Wittmann D-1000 Berlin 33, GFR

Received August 15, 1978. The synthesis of a new RNA specific bifunctional crosslinking reagent, 1.4-phenyl-diglyoxal, is described which reacts exclusively with guanosines.

The properties of the crosslinked products enabled us to develop a straightforward method for identifying the reacted nucleotides.

Results obtained with ribosomal 5S RNA of Escherichia coli demonstrate the formation of an intramolecular crosslink between guanosine-2 and guanosine-112 in the stem region.


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