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Nucleic Acids Research, 1978, Vol. 5, No. 11 4317-4328
© 1978

Articles

DNA ligase activity in UV-irradiated monkey kidney cells

M. Mezzina and S. Nocentini

Fondation Curie, Section de Biologie 26 Rue d'Ulm, 75231 Paris Cedex 05, France

Received August 18, 1978. The DNA ligase activity of monkey kidney CV-1 cells has heen measured at different stages of culture growth and after different time intervals following ultraviolet irradiation. Results indicate that:

— The level of enzyme activity is about twice higher in non synchronous, rapidly dividing cells than in confluent cultures.

— UV-irradiation of cells induces a "de novo" synthesis of DNA ligase.

— This induction is dose dependent in its extent and kinetics, and may lead to a DNA ligase level in UV-irradiated stationary cultures of the same order as observed in unirradiated exponentially growing cells.

— This induction seems to be independent of semiconservative DNA synthesis since it is not affected by fluorodeoxyuridine.


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