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Nucleic Acids Research, 1978, Vol. 5, No. 11 4417-4422
© 1978

Articles

A 1:2 crystalline complex of ApA:proflavine: a model for binding to single-stranded reigons in RNA

Stephen Neidle, Garry Taylor, Mark Sanderson, Huey-Sheng Shieh and Helen M. Berman

Dep. Biophys., Kings College, University of London 26–29 Drury Lane, London WC2B 5RL, UK The Institute for Cancer Research, The Fox Chase Cancer Center Philadelphia, PA 19111, USA

Received July 28, 1978. The structure of a 1:2 complex of adenylyl-(3',5')-adenosine phosphate and proflavine hemisulfate has been determined using the methods of x-ray crystallography. Since the ApA does not form a mini double helix, it may serve as a model for the interaction of planar molecules with single stranded nucleic acids. The dinucleotide adopts an extended conformation with the adenines in adjacent molecules forming base pairs. A most unusual feature of the molecule is that it does not obey the "rigid nucleotide" concept although none of the torsion angles occur in energetically unfavourable regions. This is most probably due to the strong interactions between the proflavine and the oligonucleotide.


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