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Nucleic Acids Research, 1978, Vol. 5, No. 4 1289-1295
© 1978

Articles

Initiation of adenovirus DNA replication does not occur via a hairpin mechanism

J. S. Sussenbach and M. G. Kuijk

Laboratory for Physiological Chemistry, State University of Utrecht Utrecht, Netherlands

Received January 3, 1977. Models have been proposed suggesting that initiation of adenovirus DNA replication might occur via a hairpin mechanism. A consequence of the models is a covalent linkage of progeny and parental DNA in newly completed molecules. Analysis of mature molecules from KB cells infected with adenovirus type 5 indicates that, if a hairpin mechanism is involved, the length of the hairpin must be shorter than 50 basepairs long. Recent nucleotide sequence analysis of the termini of adenovirus type 5 DNA (P.H.Steenbergh et al.(1977) Nucl. Acids Res.4, 4371–4389) has shown that a hairpin of this size does not exist and that therefore a hairpin mechanism is unlikely.


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