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Nucleic Acids Research, 1978, Vol. 5, No. 5 1571-1580
© 1978

Articles

Light scattering measurements supporting helical structures for chromatin in solution

A.M. Campbell1, R.I. Cotter2,* and J.F. Pardon2

1Department of Biochemistry, University of Glasgow Glasgow G12 8QQ, UK 2Searle Research Laboratories Lane End Road, High Wyconibe, Bucks, HP12 4HL, UK

*To whom requests for reprints should be addressed

Received February 1, 1978. Laser light scattering measurements have been made on a series of polynucleosomes containing from 50 to 150 nucleosomes. Radii of gyration have been determined as a function of polynucleosome length for different ionic strength solutions. The results suggest that at low ionic strength the chromatin adopts a loosely helical structure rather than a random coil. The helix becomes more regular on increasing the ionic strength, the dimensions resembling those proposed by Finch and Klug for their solenoid model.


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