Skip Navigation

This Article
Right arrow Print PDF (419K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (22)
Right arrowRequest Permissions
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Dreyer, C.
Right arrow Articles by Hausen, P.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Dreyer, C.
Right arrow Articles by Hausen, P.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1978, Vol. 5, No. 9 3325-3336
© 1978

Articles

Inhibition of mammalian RNA polymerase by 5,6-dichlororibofuranosylbenzimidazole (DRB) and DRB triphosphate

Christine Dreyer and Peter Hausen*

Max-Planck-Institut für Virusforschung, Abteilung für Zellbiologie 74 Tubingen, GFR

Received July 4, 1978.

DRB triphosphate inhibits activity of isolated RNA polymerase B, and, to a lesser extent, that of polymerase A. The same holds true for transcription in isolated nuclei. It does not act as an initiation inhibitor. In all cases, high concentrations of DRB triphosphate are required. Cells do not phosphorylate DRB to a measurable extent. hn RNA resistant to DRB is initiated with both ATP and GTP in the presence of the drug. These experiments render the hypothesis unlikely that DRB triphosphate in the cell specifically interferes with the initiation reaction of polymerase B.

*with the technical assistance of Karin Herrmann and Ursula Rössler


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Learn. Mem.Home page
S. Duvarci, K. Nader, and J. E. LeDoux
De novo mRNA synthesis is required for both consolidation and reconsolidation of fear memories in the amygdala
Learn. Mem., October 2, 2008; 15(10): 747 - 755.
[Abstract] [Full Text] [PDF]

Home page
 Antimicrob. Agents Chemother.Home page
K. Pyrc, B. J. Bosch, B. Berkhout, M. F. Jebbink, R. Dijkman, P. Rottier, and L. van der Hoek
Inhibition of Human Coronavirus NL63 Infection at Early Stages of the Replication Cycle.
Antimicrob. Agents Chemother., June 1, 2006; 50(6): 2000 - 2008.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.