Skip Navigation

This Article
Right arrow Print PDF (371K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Galbraith, A.I.
Right arrow Articles by Itzhaki, R. F.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Galbraith, A.I.
Right arrow Articles by Itzhaki, R. F.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1978, Vol. 5, No. 9 3357-3364
© 1978

Articles

Distribution of 7-methylguanine and of replication sites in the different kinetic classes of DNA from rats treated with dimethyhtitrosamine

A.I. Galbraith, Marilyn R. Chapleo* and Ruth F. Itzhaki

Paterson Laboratories, Christie Hospital and Holt Radium Institute Manchester M20 9BX, UK

Received June 23, 1978.

The distribution of 7-methylguanine in the families of repetitive and unique sequesces of rat liver chromatin DNA has been studied using the technique of DNA-DNA reassociation. Rats were injected with di [14C] nitrosamine and chromatin DNA was prepared 3 h later. The distribution of 7-methylguanine was found to be random between these classes of DNA. We have also studied chromatin DNA from rats treated with unlabelled DMN plus [3H]thymidine in this way, in order to find if DMN affects DNA synthesis within any one kinetic class. Our results suggest that there is no difference in the extent of synthesis between these classes.

* Present address: Department of Chemistry, Cancer Research Unit, University of York (U.K.)


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?




Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.