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Nucleic Acids Research, 1979, Vol. 6, No. 1 205-218
© 1979

Articles

Cell specific antiserum to chromosome scaffold proteins

Ailsa M. Campbell*, R.C. Briggs, R.E. Bird and L.S. Hnilica

Departments of Biochemistry and Molecular Biology, Vanderbilt University Nashville, TN 37232, USA

Received August 25, 1978.

Antiserum has been raised to a chromosomal protein fraction specific for Hela cells. The immunoactivity is located in the transcriptionally inactive regions of log phase chromatin. Digestion of metaphase chromosomes results in the purification of the immunoactivity in the scaffold region of the chromosomes. Extensive nuclease digestion of the scaffolds results in loss of activity. The data suggest that some of the proteins in the scaffold area are both tight binding and cell specific and may therefore play a sophisticated role in gene expression.

*Present address: Department of Biochemistry, University of Glasgow, Glasgow Gl2 8QQ, UK


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