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Nucleic Acids Research, 1979, Vol. 6, No. 2 625-643
© 1979


Articles

Aminonucleosides and their derivatives. IVI Synthesis of the 3'-amino-3'-deoxynucleoside 5'-phosphates

A.V. Azhayev, A.M. Ozols, A.S. Bushnev*, N.B. Dyatkina, S.V. Kochetkova, L.S. Victorova, M.K. Kukhanova, A.A. Krayevsky and B.P. Gottikh

Institute of Molecular Biology, USSR Academy of Sciences Vavilov St. 32, Moscow 117984 * Moscow Institute of Fine Chemical Technology M.Pirogovskaya St. 1, Moscow 119435, USSR

Received January 5, 1979. A new procedure hes been developed for the synthesis of 3'-amino-3'-deoxyribonucleosides of adenine, cytosine end uracil by condensing the trimethylsilylated bases with peracylated 3-azido-3-deoxyribose derivative. The azido group could subsequently be reduced to amino. The 5'-Phosphates of these nucleosides have been prepared and the analogues have been tested for their ability to stimulate the ribosome-catalyzed reaction of 3'(2')-O-(N-formylmethionyl)edenosine 5'-phosphate with phenylslenyl-tRNA.


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