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Nucleic Acids Research, 1979, Vol. 6, No. 5 1869-1879
© 1979

Articles

Antibiotic induced ekctrophoretic mobility shifts of DNA restriction fragments

Ellen Loucks*, George Chaconas*, Robert W. Blakesley{dagger}, Robert D. wells{dagger} and Johan H. van de Sande*

*Divisions of Medical Biochemistry, Faculty of Medicine, University of Calgary, Calgary Alberta, T2N 1N4, Canada {dagger}Department of Biochemistry, University of Wisconsin Madison, WI 53706

Received January 15, 1979. Several antibiotics , netropsin, distamycin A, actinomycin D, Hoechst 33258 and olivomycin, which demonstrate base specificity in their DNA binding properties have been found to alter the electrophoretic mobility of DNA restriction fragments in native polyacrylamide gels. The antibiotics mostly reduced the migration of larger DM fragments, but netropsin and Hoechst 33258 were observed to increase the migration rate o f several DNA fragments of intermediate size. DNA fragments of similar molecular weight which comigrate as a single gel band can at times be separated as the result of differential mobility shifts promoted by antibiotic DNA complex formations.


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