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Nucleic Acids Research, 1979, Vol. 6, No. 9 2997-3008
© 1979

Articles

A regulatory sequence near the 3' end of sea urchin histone genes

Meinrad Busslinger, Rudolf Portmann and Max L. Birnstiel

Institut für Molekularbiologie II der Universität Zürich Winterthurerstr, 266A, 8057 Zürich, Switzerland

Received May 8, 1979. The 3' flanking sequences of all five histone genes have been sequenced in the histone DNA clone h19 of the sea urchin Psammechinus miliaris. A large (23 bp) and a small (10 bp) conserved sequence was found by sequence comparison, some 29–40 bp downstream from the termination codon. 12 bases of the larger homology block show a dyad symmetry. The available sequences of clone h22 of the same species and those of the histone clones pSp2 and pSpl7 of Strongylocentrotus purpuratus, another sea urchin species, fit well into this comparison. Two types of sequences are involved in the dyad symmetry; one is H1, H3 and H4 specific, the other is H2A and H2B specific. If these conserved sequences are transcribed, a hairpin loop could form in the RNA molecules. This secondary structure might serve as a recognition signal for a regulatory protein.


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Home page
 Cold Spring Harb Symp Quant BiolHome page
M. Busslinger, D. Schumperli, and M.L. Birnstiel
Regulation of Histone Gene Expression
Cold Spring Harb Symp Quant Biol, January 1, 1985; 50(0): 665 - 670.
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