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Nucleic Acids Research, 1979, Vol. 7, No. 6 1593-1601
© 1979

Articles

Modified polynucleotides. IV. Template activity of 5-alkyhiracil-containing poly[d(A-r5U)] copolymers for DNA and RNA polymerases

J. Sàgi and L. Ötvös

Central Research Institute for Chemistry, Hungarian Academy of Sciences 1525 Budapest, PO Box 17, Hungary

Received August 26, 1979. The change gf templating properties for E. coll DNA and RNA polymera-aes of poly[d(A-r5 U)] copolymers on substitution of the uracil for 5-methyl-, 5-ethyl-, 5-n-propyl-, 5-n-butyl- or 5-n-pentyluracil, resp., was studied. All modified polymers proved to be more effective taqplate-primers than poly[d(A-U)] or poly[d(A-T)] for the DNA polymerase. Direct dependence of the tenplate-primer efficiency (Vmav/Km) value on the thermal stability of the polymers was observed. For tranicrrption the r = ethyl and n-propyl polymers were also more effective templates than poly[d(A-T)].


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