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Nucleic Acids Research, 1979, Vol. 7, No. 7 1901-1912
© 1979

Articles

The relationship between pyrimidine dimers and replicating DNA in UV-irradiated human fibro-blasts

A.R. Lehmann

MRC Cell Mutation Unit, University of Sussex Falmer, Brighton BN1 9QG, UK

Received October 8, 1979. The relationship between pyrimidine dimers (measured as endonuclease-sensitive sites) and newly-synthesized DNA has been examined 1n several different ways, with the following results:-

1. After UV-irradiation of normal human fibroblasts the frequency of pyrimidine dimer sites in sections of DNA which have been synthesized immediately before the UV-irradiation 1s similar to that in the bulk DNA.

2. The frequency of pyrimidine dimer sites in the parental strands of replicating DNA in UV-irradiated normal human fibroblasts is similar to that in the bulk DNA.

3. In UV-irradiated XP variant cells the size of DNA synthesized in the presence of caffeine immediately after UV irradiation accurately corresponds with the average interdimer distance in the parental DNA. This suggests that in this experimental situation each pyrimidine dimer gives rise to a discontinuity or a termination site in the daughter strand.


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