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Nucleic Acids Research, 1980, Vol. 8, No. 1 143-152
© 1980

Articles

Studies on the function of two adjacent N6, N6-dimethyladenosines near the 3' end of 16 S ribosomal RNA of Escherichia coli. IV. The effect of the methylgroups on ribosomal subunit interaction

Bob Poldermans, Hanny Bakker and Peter H. Van Knippenberg

Department of Biochemistry, State University of Leiden P.O. Box 9505, 2300 RA Leiden, The Netherlands

Received October 29, 1979. The effect of the presence or absence of the methylgroups of the Formula sequence near the 3' end of 16S rRNA of Escherichia coli on the interaction of the ribosomal subunits has been studied, using wild-type (methylated) and mutant (unmethylated) ribosomes. Subunit exchange experiments and competitive association experiments show a strong preference of the 50S subunit for association with methylated 30S subunits. The results indicate that the equilibrium constant of the reaction 70S Formula 30S + 50S is dependent on the methylgroups; mutant 30S·50S couples are lesss table than wild-type 30S·50S couples. It is postulated that the methylgroups also stimulate the interaction betveen 30S subunits and initiation factor IF-3.


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