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Nucleic Acids Research, 1980, Vol. 8, No. 1 85-98
© 1980

Articles

The structure of drug-deoxydinucleoside phosphate complex; generalized conformational behavior of intercalation complexes with RNA and DNA fragments

Huey-Sheng Shieh, Helen M. Berman, Michael Dabrow and Stephen Neidle*

The Institute for Cancer Research 7701 Burholme Avenue, Philadelphia. PA 19111, USA *Department of Biophysics, King's College, University of London 26-29 Drury Lane, London WC2B 5RL, UK

Received November 20, 1979. A 2:2 complex of proflavine and deoxycytidylyl-3',5'-guanosine has been crystallized and its structure determined by x-ray crystallography.

The two dinucleoside phosphate strands form self complementary duplexes with Watson Crick hydrogen bonds. One proflavin is asymmetrically intercalated between the base pairs and the other is stacked above them. The conformations of the nucleotides are unusual in that one strand has C3',C2' endo mixed sugar puckering and the other has C3',C3' endo deoxyribose sugars. These results show that the conformation of the 3' sugar is of secondary importance to the intercalated geometry.


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