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Nucleic Acids Research, 1980, Vol. 8, No. 10 2165-2172
© 1980

Articles

Upon the observation of superbeads in chromatin

S. Muyldermans*, I. Lasters**, L. Wyns and R. Hamers

Vrije Universiteit Brussel, Algemene Biologie Paardenstraat 65, 1640 Saint-Genesius-Rode, Belgium

Received March 31, 1980.

There exist some indications that nucleases recognize "superbeads" in chromatin. We show that a chromatin extract of rat liver which contains so-called "superbead"-peaks can be separated in a Mg++ soluble and a Mg++ insoluble fraction. The Mg++ insoluble fraction contains the full complement of histones and the expected DNA fragments, but has lost the characteristic peaks in sucrosegradient profiles. These discrete peaks are found in the Mg2+ soluble fraction of the chromatin extract. We give evidence that these peaks are RNP particles on the basis of their protein- and nucleic acid contents.

*Fellow of the I.W.O.N.L. (Instituut voor de aanmoediging van wetenschappelijk onderzoek in nijverheid en landbouw).

**Fellow supported by a Solvay grant.


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