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Nucleic Acids Research, 1980, Vol. 8, No. 12 2561-2576
© 1980

Articles

Complete nucleotide suquence of the haemagglutinin gene from a human influenza virus of the Hong Kong subtype

G.W. Both and M.J. Sleigh

CSIRO, Molecular and Cellular Biology Unit P.O. Box 184, North Ryde, N.S.W. 2113, Australia

Received May 19, 1980. The complete nucleotide sequence has been determined for a cloned double-stranded DNA copy of the haenagglutinin gene from the human influenza strain A/NT/60/68/29C, a laboratory-isolated variant of A/NT/60/68, an early strain of the Hong Kong subtype. The gene is 1765 nucleotides long and contains information sufficient to code for a protein of 566 amir acids, which includes a hydrophobic leader peptide (16 residues), HA1 (328), HA2 (221) and an arginine residue which joins the HA subunits. Comparison of the predicted amino acid sequence for 29C hasmagglutinin with protein sequence data available for HA from other influenza strains shows that no potential coding information is lost by processing of the mRNA.

A comparison of the amino acid sequences predicted from the gene sequences for 29C and fowl plague virus haemagglutinins, (1) indicates the extent to which changes can occur in the primary sequence of different regions of the protein, while maintaining essential structure and function.


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