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Nucleic Acids Research, 1980, Vol. 8, No. 12 2751-2770
© 1980

Articles

The number of charge-charge interactions stabilizing the ends of nucleosome DNA

James D. McGhee and Gary Felsenfeld

Laboratory of Molecular Biology, National Institutes of Arthritis, Metabolism and Digestive Diseases, National Institutes of Health Bethesda, MD 20205, USA

Received March 21, 1980. It has been shown by others that the melting of DNA in the nucleosome core particle is biphasic (ref.1) and that the initial denaturation phase is due to melting of the DNA termini (refs. 1 & 2). We analyze the salt dependence of the melting temperature of this first transition and estimate that only 15% of the phosphates of the DNA termini are involved in intimate charge-charge interactions with histones. (The simplest model yields {small tilde}9% whereas a calculated overestimate yields {small tilde}21% neutralization.) This is a surprisingly small number of interactions but we suggest that it may nonotheless be representative of all the core particle DNA.


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J. Strauss and L. Maher 3rd
DNA bending by asymmetric phosphate neutralization
Science, December 16, 1994; 266(5192): 1829 - 1834.
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