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Nucleic Acids Research, 1980, Vol. 8, No. 14 3143-3156
© 1980

MOLECULAR BIOLOGY

Structure of the constant and 3' untranslated regions of the murine Balb/c {gamma}2a heavy chain messenger RNA

Jean-Louis Sikorav, Charles Auffray and François Rougeon

Unite de Genetique et Biochimie du Developpement, E.R.A. C.N.R.S. 851, Institut Pasteur 28, rue du Docteur Roux, 75724 Paris Cedex 15, France

Received May 27, 1980. The complete sequence for the constant and 3' untranslated regions of a mouse {gamma}2a immunoglobulin heavy chain mRNA is reported. The sequence is 1093 nucleotides long coding for the CH1 (amino-acids 118–214), the Hinge (215–230), the CH2 (231–340) and the CH3 (341–447). The 3' untranslated region is 103 nucleotides long preceding the poly(A). The nucleotide sequence predicts as in the case for {gamma}1 and {gamma}2b heavy chains an additional lysine residue before the termination codon. This sequence has been compared to the corresponding sequences of {gamma}1 and {gamma}2b heavy chain mRNAs. These sequences are respectively 75% and 84% homologous. The CH2 domains of {gamma}2a and {gamma}2b are 95% homologous at the nucleotide level. The cross-over point of a {gamma}2a {gamma}2b heavy chain variant is located in a segment of 73 perfectly matching nucleotides. The 3' non coding regions of {gamma}2a and {gamma}2b are 89% homologous.


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