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Nucleic Acids Research, 1980, Vol. 8, No. 15 3413-3426
© 1980

CHEMISTRY

A route to RNA with an alkylating group at the 5'-triphosphate residue

M.A. Grachev, A.A. Mustaev and S.I. Oshevski

Novosibirsk Institute of Organic Chemistry, Siberian Division of the Academy of Sciences Novosibirsk 90, USSR

Received May 15, 1980. Reaction of ATP with N,N,N'-tris(2-chloroethyl),N'(p-formylphenyl)propylenediamine-1,3 (abbreviation Cl3R) afforded a {gamma}-ester of ATP (abbreviation CLRpppA)-the product of alkylation by an aliphatic nitrogen mustard residue of Cl3R. The alkylating activity of the aromatic nitrogen mustard residue of ClRpppA is suppressed by the electron-acceptor effect of the p-fomyl group. ClRpppA is a substrate of RNA-polymerase, and affords RNA with ClRpppA-residues at the 5'-termini.


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