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Nucleic Acids Research, 1980, Vol. 8, No. 16 3659-3672
© 1980

MOLECULAR BIOLOGY

Secondary structures for splice junctions in eukaryotic and viral messenger RNA precursors

Bruce C. Trapnell, Paul Tolstoshev and Ronald G. Crystal

Pulmonary Branch, National Heart, Lung and Blood Institute 6D06, Building 10, National Institutes of Health, Bethesda, MD 20205, USA

Received July 24, 1980. Thermodynamically stable secondary structures have been found for adjacent splice junctions of 17 introns from 10 eukaryotic and viral mRNA precursors. Complementary regions in these structures position the exons to be ligated in a favourable orientation for splicing. The possible role of these structures in a general splicing mechanism is described.


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