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Nucleic Acids Research, 1980, Vol. 8, No. 16 3695-3708
© 1980

MOLECULAR BIOLOGY

Circular dichroism spectra show that repeating dinucleotide DNAs may form helices in which every other best is looped out

Donald M. Gray, Marilyn Vaughan, Robert L. Ratcliff and F.Newton Hayes*

Program in Molecular Biology, University of Texas at Dallas P.O. Box 688, Richardson, TX 75080 Genetics Group, Life Sciences Division, Los Alamos Scientific Laboratory, University of California Los Alamos, NM 87545, USA

Received May 12, 1980.

We have found that the CD spectrum of poly[d(C-T)] undergoes a marked change upon protonation, taking on the unmistakable features of the spectrum of poly[d(C)·d(C+)]. The acid poly[d(C-T)] structure appears to be one in which each of the T residues is individually looped out of a helix formed by stacked C·C+ base pairs. We also present data for poly[d(C-A)] and review data for the other four possible repeating DNA dinucleotide sequences. These data show that self-complexes in which up to 50% of the residues are extrahelical may be unexceptional.

*Deceased. A friend and colleague we greatly miss.


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