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Nucleic Acids Research, 1980, Vol. 8, No. 16 3729-3742
© 1980

MOLECULAR BIOLOGY

The structure of the covalent linkage between proteins and RNA in encephalomyocarditis virus

A.B. Vartapetian, Yu.F. Drygin*, K.M. Chumakov and A.A. Bogdanov

A.N.Belozersky Laboratory of Molecular Biology and Bioorganic Chemistry, Moscow State University Moscow, USSR

*To whom the correspondence should be addressed

Received March 25, 1980. Two proteins, VPgA and VPgB, are covalently bound to the virion RNA of encephalomyocarditis (EMC) virus. Their molecular weights, as determined by polyacrylamide gel electrophoresis in the presence of sodium dodecyl sulfate are 10,000 and 8,000, respectively. A study of nucleotide-peptides isolated from VPg-RNA compound has shown that VPgA is bound to the 5'-terminal nucleotide of RNA by a phosphodiester bond. The 5'-terminal nucleotide of RNA is uridylic acid. It is the hydroxy group of the Tyr residue of VPgA that is involved in the formation of the linkage with RNA. VPgB-RNA seems to be similar to VPgA-RNA both in the structure of the RNA-protein linkage and localization of VPgB on RNA.


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