Skip Navigation

This Article
Right arrow Print PDF (255K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Sanyal, N. K.
Right arrow Articles by Roychoudhury, M.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Sanyal, N. K.
Right arrow Articles by Roychoudhury, M.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1980, Vol. 8, No. 17 3975-3982
© 1980

CHEMISTRY

Role of interaction energy in the Specificity of transcription. I-The Watson Crick G-C base pair template

Nitish K. Sanyal, U. Kumar and Mihir Roychoudhury

Department of Physics, University of Gorakhpur Gorakhpur 273001, India

Received May 27, 1980. The purpose of this work is to show that the selectivity of the nucleotide bases in RNA transcription c an be inferred, in principle from the DNA base pair - RNa base interaction. The catalytic role of enzymes in this process is, therefore, only to form the sugar - phosphate backbone. A systematic study for the evaluation of the interaction energy of the DNA base pair with the entsrant RNA bases have been undertaken to elucidate the aforesaid mechanism. Electrostatic hard sphere approximation of Nash and Bradley1 has been employed. Non bonded induced dipole and London dispersion forces are not taken into account. The present communication gives the results of computations of the interaction energy of the four RNA bases. The results have been discussed with reference to Stent's and Zubay's schemes of RNA transcription.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Nucleic Acids ResHome page
R. P. Ojha and R. K. Tiwari
Triplex hydration: nanosecond molecular dynamics simulation of the solvated triplex formed by mixed sequences
Nucleic Acids Res., November 1, 2003; 31(21): 6373 - 6380.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.