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Nucleic Acids Research, 1980, Vol. 8, No. 18 4155-4164
© 1980

MOLECULAR BIOLOGY

Proteins of metaphase chromosomes and interphase chromatin

Virginia P. Wray1, Sarah C.R. Elgin2 and Wayne Wray3,

1Dep. Cell Biology, Univ. Texas System Cancer Cent., M.D. Anderson Hospital and Tumor Inst. Houston, TX 77030 2Dep. Biochemistry and Molecular Biology, Harvard Univ. Cambridge, MA 02138 3Dep. Cell Biology, Baylor Coll. Medicine Houston, TX 77030, USA

Address communication to: Dr. Wayne Wray, Department of Cell Biology, Baylor College of Medicine, 1200 Moursund, Houston, TX 77030, USA

Received June 17, 1980. Metaphase chromosomal and interphase chromatin proteins from cells of two species have been campared by polyacrylamide gel electrophoresis. Consistent, common changes in the quantitative distribution of the nonhistone chromosomal proteins are observed in both species. Proteins of ca. 65,000 and 68,000 MW are enriched In interphase chromatin while proteins of ca. 50,000 and 200,000 are more prominent components of metaphase chromosomes. A group of proteins of 90,000–100,000 are also increased in metaphase chromosomes compared to interphase chromatin. By two dimensional gel analysis, the nost abundant proteins from chromosomes of both cell types are similar, suggesting a structural role for these nonhistone proteins (1).


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