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Nucleic Acids Research, 1980, Vol. 8, No. 18 4247-4258
© 1980

MOLECULAR BIOLOGY

The nucleotide sequence of the major ß-globin mRNA from Xenopus laevis

Jeffrey G. Williams, Robert M. Kay and Roger K. Patient

Imperial Cancer Research Fund, Mill Hill Laboratories Burtonhole Lane, London, NW7 1AD, UK

Received July 16, 1980. The nucleotide sequence of a cloned fragment containing an almost complete copy of the mRNA encoding the major adult ß-globin polypeptide in Xenopus laevis, the South African Clawed Toad, is presented. A procedure for strand separation by hybridization to complementary mRNA was used to determine some of the sequence and this technique is described. The complete amino acid sequence of the polypeptide has been deduced and comparison with other vertebrate ß-globins reveals several highly conserved, and therefore potentially important, regions of the protein. The sequence of ß-globin mRNA has been determined in several mammals, and in the chicken. Thus we have searched for conserved regions in the non-coding portions of these mRNA sequences, which encode the same protein, but which have been evolving separately for several hundred million years.


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