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Nucleic Acids Research, 1980, Vol. 8, No. 18 4305-4320
© 1980

CHEMISTRY

Polypurine DNAs and RNAs form secondary structures which may be tetra-stranded

Jeremy S. Lee, David H. Evans and A.Richard Morgan

Department of Biochemistry, University of Alberta Edmonton, Alberta, T6G 2H7, Canada

Received May 9, 1980. Polypurine DNAs and RNAs containing at least 33% guanine form a stable secondary structure at neutral pH and moderate ionic strengths. The tm's of the polymers increase with increasing guanine content. To eliminate possible structures three novel polymers, d(Gn2A)n, d(Gm6A)n and d(IA)n*, as well as the random copolymer r(G.A)n were studied. Both d(Gn2A)n and d(IA)n can form a secondary structure whereas d(Gm6A)n and r(G,A)n cannot. Model building suggested two possible structures, one a duplex and the other a tetra-stranded polymer. The latter is considered to be the more likely, since previous X-ray diffraction studies have shown that rGn and rIn are tetra-stranded. Circular dichroism spectra are also consistent with such an interpretation.


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