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Nucleic Acids Research, 1980, Vol. 8, No. 19 4545-4562
© 1980

CHEMISTRY

Some rules in the ordering of nucleotides in the DNA

Ruth Nussinov*

Department of Structural Chemistry, Weizmann Institute of Science Rehovot, Israel

Received July 4, 1980.

Natural DNA sequences contain distinct nearest neighbor patterns. Eukaryotic as well as prokaryotic sequences show a consistent hierarchy in the frequencies of appearance of most doublets.

*Present address: Department of Chemistry and Melvin Calvin Laboratory, University of California, Berkeley, Berkeley, CA 94720, USA


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