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Nucleic Acids Research, 1980, Vol. 8, No. 20 4671-4680
© 1980


MOLECULAR BIOLOGY

Histone 2B can be modified by the attachment of ubiquitin

Michael H.P. West and William M. Bonner

Laboratory of Molecular Pharmacology, Developmental Therapeutics Program, Division of Cancer Treatment, National Cancer Institute, National Institutes of Health Bethesda, MD 20205, USA

Received July 24, 1980. Histone 2B in mouse and man can be modified by the post-translational additition of ubiquitin. In mouse L1210 cells, both H2B variants are modified, however only to the extent of 1–1.5% compared with about 11% of H2A. Analysis of cyanogen bromide peptides shows that ubiquitin is attached to the C-terminal part of the histone.


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