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Nucleic Acids Research, 1980, Vol. 8, No. 20 4791-4802
© 1980

MOLECULAR BIOLOGY

Identification by nucleotide sequence analysis of a goat pseudoglobin gene

Michael L. Cleary, Joel R. Haynes, Eric A. Schon and Jerry B. Lingrel

University of Cincinnati College of Medicine, Department of Biological Chemistry 231 Bethesda Avenue, Cincinnati, OH 45267, USA

Received July 29, 1980. We have recently prepared a recombinant library of goat genomic DNA and have isolated clones containing the known goat globin genes. These include the {alpha}, {gamma}, ßC and ßA genes. In addition to these, another ß-like sequence has been observed. In this communication we report the complete nucleotide sequence of this gene, excluding a portion of the large intervening sequence. Several features suggest that this is a non-functional or pseudoglobin gene. The alterations include a frameshift mutation, substitution of the heme-binding histidines, a mutated termination codon, a change in the GT/AG excision sequence of the 5' end of the first intervening sequence, an AT rich sequence in the 3' untranslated region, and a mutated Hogness-Goldberg box. We conclude that this gene cannot function in the synthesis of globin.


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