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Nucleic Acids Research, 1980, Vol. 8, No. 22 5213-5222
© 1980

MOLECULAR BIOLOGY

A mammalian mitochondrial serine transfer RNA lacking the "dihydrouridine" loop and stem

M.H.L. de Bruijn, P.H. Schreier*, I.C. Eperon, B.G. Barrell, E.Y. Chen, P.W. Armstrong, J.F.H. Wong and B.A. Roe

MRC Laboratory of Molecular Biology Hills Road, Cambridge CB2 2QH, UK Chemistry Department, Kent State University Kent, OH 44242, USA

Received September 22, 1980.

A unique transfer DNA has been identified in human and bovine mitochondria that lacks the "dihydrouridine" loop and stem structure. This tRNA ie mitochondrially coded as shown by DNA sequence analysis of the human and bovine mitochondrial DNA. Sequence analysis of the INA shows that it is post-transcriptionally modified by the addition of CCA at the 3' terminus and that at least one base is modified. As predicted by its anticodon (GCU, corresponding to the serine codons AGU/C) this tRNA can be aminoacylated with serine when purified mitochondria are incubated in a medium containing 3H-serine.

*Present address: Institut für Genetik der Universität, 5 Koln 41, Weyertal 121, West Germany.


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