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Nucleic Acids Research, 1980, Vol. 8, No. 22 5507-5518
© 1980

MOLECULAR BIOLOGY

Solid-phase synthesis of polynucleotides. IV. Usage of polystyrene resins for the synthesis of polydeoxyribonucleotides by the phosphotriester method

Ken-ichi Miyoshi, Rene Arentzen, Ting Huang and Keiichi Itakura

Division of Biology, Molecular Genetics Section, City of Hope Research Institute Duarte, CA 91010, USA

Received July 25, 1980. Contrary to the expectation, the Merrifield polystyrene resin, 2% cross-linked by divinylbenzene, is as efficient as the polyacrylmorpholide resin for the synthesis of polydeoxyribonucleotides using a phosphotriester method. On the Merrifield resin, the tetradecamer, dTpCpGpTpCpApApCpTpGpGpCpTpT, and the hexadecamer, dCpCpApGpTpCpApCpGpApCpGpTpTpGpT, were synthesized by the phosphotriester method using di and trinucleotide blocks as coupling units.


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