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Nucleic Acids Research, 1980, Vol. 8, No. 23 5835-5844
© 1980

MOLECULAR BIOLOGY

Mammalian cell functions mediating recombination of genetic elements

Peter Upcroft, Bernard Carter and Chev Kidson

Queensland Institute of Medical Research Brisbane, Australia 4006

Received September 25, 1980. Recombination of segments of the SV40 genome by a variety of mechanisms is described. These include the faithful joining of linear segments that have flush termini as opposed to previously described cohesive or resected termini. Lack of involvement of viral proteins has been demonstrated for recorbination of segments with homologous overlapping termini, but probably applies also to the other joining reactions.

Segments of the genome that have been cleaved in such a manner as to be unable to manufacture any known viral proteins are neutral elements of genetic information, incapable of selection by replication or biological function until recombined. These recombination functions presumably are available to the host cell and any element of genetic information that can be generated in that cell.


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