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Nucleic Acids Research, 1981, Vol. 9, No. 1 121-131
© 1981

MOLECULAR BIOLOGY

High mobility group proteins 1 and 2 are present in simian virus 40 provirions, but not in virions

Franca La Bella{dagger}, Massimo Romani{dagger}, Cesare Vesco$ and Giorgio Vidali{dagger},*

{dagger}The Rockefeller University New York, NY 10021, USA $Laboratorio di Biologia Cellulare CNR, 00196 Roma, Italy

* To whom reprint requests should be sent.

Received July 14, 1980. Viral particles at the late stages of SV40 morphogenesis were examined for the presence of HMG proteins 1 and 2, by an immunochemical method involving the transfer of proteins from polyacrylamide gels to nitrocellulose membranes. It was found that these proteins are present in SV40 provirions, in which histone H1 is still associated with viral chromatin, but absent in mature SV40 virions.


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