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Nucleic Acids Research, 1981, Vol. 9, No. 11 2577-2588
© 1981

MOLECULAR BIOLOGY

Penicillinase from Bacillus licheniformis: nucleotide sequence of the gene and implications for the biosynthesis of a secretory protein in a Gram-positive bacterium

Kristina Neugebauer*, Rolf Sprengel and Heinz Schaller

Mikrobiologie, Universität Heidelberg Im Neuenheimer Feld 230, 6900 Heidelberg, GFR

*Present address: Institut fü Zell- und Tumorbiologie, Deutsches Krebsforschungszentrum, Im Neuenheimer Feld 280, 6900 Heidelberg, FRG.

Received April 30, 1981. The gene for the penicillinase from B. licheniformis has been cloned in a functional state on a 1.5 kb DNA fragment and its nucleotide sequence has been determined. A sequence of 307 amino acid residues is infered for the penicillinase precursor. Of these 34 amino acids precede the sequence of the secreted form of the enzyme. This peptide extension shows the features of a signal for secretion and also provides the hydrophobic anchor for the membrane-bound form of the enzyme.


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