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Nucleic Acids Research, 1981, Vol. 9, No. 12 2691-2697
© 1981


MOLECULAR BIOLOGY

The nucleotide sequence of rat {alpha}-tubulin: 3'-end characteristics, and evolutionary conservation

I. Ginzburg, L. Behar, D. Givol* and U.Z. Littauer

Department of Neurobiology, The Weizmann Institute of Science, Rehovot, Israel *Department of Chemical Immunology, The Weizmann Institute of Science, Rehovot, Israel

Received April 30, 1981. The structure and sequence of rat {alpha}-tubulin cDNA clone is being described. The 3'-end of the coding region contains the codon for a C-terminal tyrosine, which was previously considered to be post-translationally added to the completed polypeptide chain. A close homology in the coding sequence is observed when {alpha}-tubulin from rat and chick are compared, while the 3'-non-translated region has diverged considerably.


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