Skip Navigation

This Article
Right arrow Print PDF (1869K)
Right arrow Alert me when this article is cited
Right arrow Alert me if a correction is posted
Services
Right arrow Email this article to a friend
Right arrow Similar articles in this journal
Right arrow Similar articles in PubMed
Right arrow Alert me to new issues of the journal
Right arrow Add to My Personal Archive
Right arrow Download to citation manager
Right arrow Search for citing articles in:
ISI Web of Science (31)
Right arrow Commercial Re-use Guidelines
for Open Access NAR Content
Google Scholar
Right arrow Articles by Lavery, R.
Right arrow Articles by Pullman, B.
Right arrow Search for Related Content
PubMed
Right arrow PubMed Citation
Right arrow Articles by Lavery, R.
Right arrow Articles by Pullman, B.
Social Bookmarking
Add to CiteULike   Add to Connotea   Add to Del.icio.us  
What's this?

Nucleic Acids Research, 1981, Vol. 9, No. 15 3765-3777
© 1981

CHEMISTRY

The molecular electrostatic potential, steric accessibility and hydration of Dickerson's B-DNA dodecamer d(CpGpCpGpApApTpTpCpGpCpG)

Richard Lavery and Bernard Pullman

Institut de Biologie Physico-Chimique, Laboratoire de Biochimie Théorique, associé au C.N.R.S. 13, rue Pierre et Marie Curie, 75005 Paris, France

Received June 15, 1981. The paper presents the results of computation of the electrostatic potential and steric accessibility of the B-DNA self-complementary dodecamer CGCGAATTCGCG following the geometry of the recent single crystal structure of Dickerson et al. This structure shows significant variations from classical B-DNA ; their influences on the calculated properties are discussed. The resultsare related to general features of hydration of the crystal. A particularly significant general finding concernsthe greater negative potential in the center of the oligonucleotide helix than at its extremities. This will be a general feature of such short helices, independant of their base sequence. It may have important implications for the reactivity of DNA oligomers.


Add to CiteULike CiteULike   Add to Connotea Connotea   Add to Del.icio.us Del.icio.us    What's this?


This article has been cited by other articles:


Home page
 Proc. Natl. Acad. Sci. USAHome page
S. Y. Ponomarev, K. M. Thayer, and D. L. Beveridge
Ion motions in molecular dynamics simulations on DNA
PNAS, October 12, 2004; 101(41): 14771 - 14775.
[Abstract] [Full Text] [PDF]

Home page
 Nucleic Acids ResHome page
D. Hamelberg, L. D. Williams, and W. D. Wilson
Effect of a neutralized phosphate backbone on the minor groove of B-DNA: molecular dynamics simulation studies
Nucleic Acids Res., August 15, 2002; 30(16): 3615 - 3623.
[Abstract] [Full Text] [PDF]


Disclaimer:
Please note that abstracts for content published before 1996 were created through digital scanning and may therefore not exactly replicate the text of the original print issues. All efforts have been made to ensure accuracy, but the Publisher will not be held responsible for any remaining inaccuracies. If you require any further clarification, please contact our Customer Services Department.