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Nucleic Acids Research, 1981, Vol. 9, No. 18 4783-4798
© 1981

CHEMISTRY

The transitions between left- and right-handed forms of poly(dG-dC)

Valery I. Ivanov and Elvira E. Minyat

Institute of Molecular Biology, Academy of Sciences of the USSR Vavilov str., 32, Moscow 117984, USSR

Received April 10, 1981. The circular dichroism study of water/trifluoroethanol (TFE) solutions of poly(dG-dC) has revealed the following: The polynucleotide is present as a Formula form up to a TPE content of 60% (v/v) or less. Then, a cooperative transition into a left-handed Formula form occurs. Within the region of 66-78% TFE, a continuous non-cooperative change is going on which can be attributed to an intrafamily transition within the family of Formula forms. At last, in the interval of 80-84% TFE, a second cooperative transition, probably, Formula – Formula, is realized. Both transitions, Formula – Formula and Formula – Formula, show slow kinetics (10–60 min) while the direct transitions from the Formula to Formula form taking less than 10 sec. The length of cooperativety for the Formula – Formula transition, {nu}0 = 25 base pairs was estimated using spermine molecules. Spermine was found to induce the Formula to Formula transition in the (dG-dC) sequences even in the absence of TFE which might be biologically interesting.


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