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Nucleic Acids Research, 1981, Vol. 9, No. 19 4981-4996
© 1981

MOLECULAR BIOLOGY

The endogenous proviral mouse mammary tumor virus genes of the GR mouse are not identical and only one corresponds to the exogenous virus

P. Herrlich, N.E. Hynes, H. Ponta, U. Rahmsdorf, N. Kennedy and B. Groner

Kernforschungszentrum Karlsruhe, Institut für Genetik und für Toxikologie Postfach 3640, D 7500 Karlsruhe 1, GFR

Received June 26, 1981. The endogenous proviral copies of mouse mammary tumor virus (MMTV) were selected from a gene library of GR mouse DNA. We obtained five different {lambda}.MMTV recombinant clones. Four of them correspond to the 3' Eco RI fragments of the endogenous proviruses and one comprises an intact MMTV provirus with 2 to 3 kb of flanking mouse genomic DNA. Heteroduplex formation followed by Sl digestion under stringent conditions shows that there is nucleotide sequence heterology among the cloned endogenous proviral copies. Only one endogenous proviral copy, associated with the mtv-2 locus, was found to be totally homologous to the exogenous proviral DNA.


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