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Nucleic Acids Research, 1981, Vol. 9, No. 2 247-266
© 1981

MOLECULAR BIOLOGY

The absence of introns within a human fibroblast interferon gene

M. Houghton, I.J. Jackson*, A.G. Porter, S.M. Doel, G.H. Catlin, C. Barber and N.H. Carey

Molecular Genetics Department, Searle Research & Development. Division of C.D.Searle & Co. Ltd. P.O. Box 53, Lane End Road, High Wycombe, Bucks HP12 4HL. UK *Biochemistry Department, St. Mary's Hospital Medical School Praed Street. London, UK

Received November 20, 1980. Experiments in which immobilised restriction fragments of genomic DNA were hybridised with a cloned human fibroblast interferon cDNA indicate that the homologous chromosomal genes exist in only one basic arrangement. This is in marked contrast to recent studies by Nagata et al. (1) showing that there are at least eight gene arrangements for human leukocyte interferon.

Having isolated a chromosomal human fibroblast interferon gene from a gene bank, we conclude from nucleotide sequencing studies that there is a complete absence of introns within the mRNA-coding region. In view of a similar observation recently made for a human leukocyte interferon gene (1), it would appear as if interferon genes in general are unlike the vast majority of eukaryote genes in this respect.


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