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Nucleic Acids Research, 1981, Vol. 9, No. 2 365-373
© 1981

MOLECULAR BIOLOGY

Transcriptional errors and ambiguity resulting from the presence of 1,N6-ethenoadenosine or 3,N4-ethenocytidine in polyribonucleotides

S. Spengler and B. Singer

Department of Molecular Biology and Virus Laboratory, University of California Berkeley, CA 94720, USA

Received November 5, 1980. 1,N6-Ethenoadenosine ({varepsilon}A) and 3,N4-Ethenocytidine ({varepsilon}C) in copolymers with unmodifid nucleosides were transcribed using DNA-dependent RNA polymerase in the presence of Mn2+. Nearest neighbor analysis of the products showed that {varepsilon}A directed incorporation of A>U>C while {varepsilon}C directed the incorporation of U≥A»C. Neither directed G into the complementary polymer. Such misincorporations resulting from {varepsilon}A and {varepsilon}C, compounds that are formed in vivo by the carcinogen vinyl chloride, may have a biological role as promutagens.


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